Set between the events of SAW and SAW II, John, desperate and sick, travels to Mexico to undergo an experimental and very risky treatment in hopes of curing his deadly cancer. However, the whole operation turns out to be a fraud to deceive those most vulnerable. Full of rage and with a lurid new purpose, John will resume his work as a serial killer and give the tricksters a taste of their own medicine. Under the watchful eye of Jigsaw, the youngsters will face the most ingenious, deadly and torturous traps in a visceral and merciless game.